Active Ingredient in Marijuana Kills Brain Cancer Cells

Active Ingredient in Marijuana Kills Brain Cancer Cells

03.31.09, 08:00 PM EDT

Experts say finding worth further study, but patients shouldn’t light up just yet

WEDNESDAY, April 1 (HealthDay News) — New research out of Spain suggests that THC — the active ingredient in marijuana — appears to prompt the death of brain cancer cells.

The finding is based on work with mice designed to carry human cancer tumors, as well as from an analysis of THC’s impact on tumor cells extracted from two patients coping with a highly aggressive form of brain cancer.

Explaining that the introduction of THC into the brain triggers a cellular self-digestion process known as “autophagy,” study co-author Guillermo Velasco said his team has isolated the specific pathway by which this process unfolds, and noted that it appears “to kill cancer cells, while it does not affect normal cells.”

Velasco is with the department of biochemistry and molecular biology in the School of Biology at Complutense University in Madrid. The findings were published in the April issue of The Journal of Clinical Investigation.

The Spanish researchers focused on two patients suffering from “recurrent glioblastoma multiforme,” a fast-moving form of brain cancer. Both patients had been enrolled in a clinical trial designed to test THC’s potential as a cancer therapy.

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Drug money saved banks in global crisis, claims UN advisor

Drug money saved banks in global crisis, claims UN advisor

Drugs and crime chief says $352bn in criminal proceeds was effectively laundered by financial institutions

Drugs money worth billions of dollars kept the financial system afloat at the height of the global crisis, the United Nations’ drugs and crime tsar has told the Observer.

Antonio Maria Costa, head of the UN Office on Drugs and Crime, said he has seen evidence that the proceeds of organised crime were “the only liquid investment capital” available to some banks on the brink of collapse last year. He said that a majority of the $352bn (£216bn) of drugs profits was absorbed into the economic system as a result.

This will raise questions about crime’s influence on the economic system at times of crisis. It will also prompt further examination of the banking sector as world leaders, including Barack Obama and Gordon Brown, call for new International Monetary Fund regulations. Speaking from his office in Vienna, Costa said evidence that illegal money was being absorbed into the financial system was first drawn to his attention by intelligence agencies and prosecutors around 18 months ago. “In many instances, the money from drugs was the only liquid investment capital. In the second half of 2008, liquidity was the banking system’s main problem and hence liquid capital became an important factor,” he said.

Some of the evidence put before his office indicated that gang money was used to save some banks from collapse when lending seized up, he said.

“Inter-bank loans were funded by money that originated from the drugs trade and other illegal activities… There were signs that some banks were rescued that way.” Costa declined to identify countries or banks that may have received any drugs money, saying that would be inappropriate because his office is supposed to address the problem, not apportion blame. But he said the money is now a part of the official system and had been effectively laundered.

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American Medical Association rethinking pot prohibition?

American Medical Association rethinking pot prohibition?

By Daniel Tencer
Tuesday, November 10th, 2009 — 1:05 pm

American Medical Association rethinking pot prohibition?

The American Medical Association on Tuesday issued a cautious but historically significant call to change America’s marijuana prohibition laws, urging a “review” of the drug’s status as a Schedule I drug.

At a meeting in Houston, the AMA’s House of Delegates adopted a new policy that calls for “marijuana’s status as a federal Schedule I controlled substance be reviewed with the goal of facilitating the conduct of clinical research and development of cannabinoid-based medicines, and alternate delivery methods.”

That does not mean the AMA supports the legalization or decriminalization of marijuana.

Schedule I drugs are those considered to have no medical benefit and to be harmful when used under any circumstances. As such, marijuana is currently grouped by the federal government with drugs like heroin and LSD. By comparison, cocaine and methamphetamines are classified as Schedule II drugs, which may have some clinical benefits when used in the proper circumstances. The AMA’s stance could simply result in the rescheduling of marijuana as a controlled substance that has some medical benefit.

However, Aaron Houston, director of government relations for the Marijuana Policy Project, calls the move “historic” all the same, noting that it comes from “what has historically been America’s most cautious and conservative major medical organization.”

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If Marijuana Production Were Legal: Projected Tax Revenues, by State

Marijuana might cause new cell growth in the brain

Marijuana might cause new cell growth in the brain

  • 22:00 13 October 2005 by Kurt Kleiner

A synthetic chemical similar to the active ingredient in marijuana makes new cells grow in rat brains. What is more, in rats this cell growth appears to be linked with reducing anxiety and depression. The results suggest that marijuana, or its derivatives, could actually be good for the brain.

In mammals, new nerve cells are constantly being produced in a part of the brain called the hippocampus, which is associated with learning, memory, anxiety and depression. Other recreational drugs, such as alcohol, nicotine and cocaine, have been shown to suppress this new growth. Xia Zhang of the University of Saskatchewan in Saskatoon, Canada, and colleagues decided to see what effects a synthetic cannabinoid called HU210 had on rats’ brains.

They found that giving rats high doses of HU210 twice a day for 10 days increased the rate of nerve cell formation, or neurogenesis, in the hippocampus by about 40%.

Just like Prozac?

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